The purpose of researches was studying and com-parative analysis of the influence of biologically active preparations on a course of disease in the minks exper-imentally infected with cultural isolate of the virus "Sap-phire" AIM (Aleutian illness of minks). Three groups of minks (two experimental and one control) of dark brown color at the age of 10 months were created (on 20 ani-mals in each). The animals of experimental groups were infected with cultural isolate of the virus "Sapphire" of ABN in a dose on 2.0 cm3 intraperitoneally. Not infected minks served as control. To twenty minks of the first experimental group three days before infection and fur-ther five-day courses with an interval of 10 days added infeed mix subalin in a dose 0.2 and 0.5 · 109. In addi-tion for the purpose of carrying out comparative analysis experimental groups of infected minks to which accord-ing to similar scheme in feed mix interferon of the EU-lipint in a dose of 200 thousand and 500 thousand ME was added were created. In the analysis of results of biochemical and hematologic blood tests for the 45th day animals of experimental group had reliable de-crease in the level of general protein of serum of blood by 14 %, the decrease in the contents γ-globulins for 92 % in comparison with those indicators of control group. The minks of the RIEOF experimental groups for the 14th day showed positive result, for the 21st and 30th day doubtful, and for the 45th days of experiment negative result.The application of biologically active preparations in the complex of symptomatic treatment of patients with Aleutian illness of minks had positive immunomodelling impact on exchange processes in an organism of animals and promotes increase of indica-tors of safety of young growth, quality of fur and profita-bility of production.